The Insecticide Avermectin Bla Activates A Chloride Channel in Crayfish Muscle Membrane
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چکیده
منابع مشابه
The insecticide avermectin b (la) activates a chloride channel in crayfish muscle membrane.
Effects of avermectin Bl a (AVM) have been tested on excised outside-out or inside-out patches of crayfish stomach muscle membrane. Continuous supervision of AVM (0.1-1 pmoll (-1)) to the outside-out patches induced openings of channels(22 pS) which were similar in conductance and kinetics to the chloride channels activated by glutamate, quisqualic acid, ibotenic acid and nicotinic agonists,whe...
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Low-conductance chloride channel from skeletal muscle SR vesicles of the crayfish Astacus fluviatilis was incorporated into planar lipid bilayers and its basic characteristics were investigated. The channel has a relatively low unitary conductance of 26 pS in symmetrical 160 mmol/l choline-chloride. The dependence of the channel conductance on Cl- concentration shows saturating behavior with a ...
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Introduction: Recent studies have shown the presence of Cl- channels in heart and liver mitochondrial membranes. In this work, we have characterized the functional profile of a Cl- channel from rat brain mitochondria. Methods: After removing and homogenizing the rat brain, the supernatant was separately centrifuged in MSEdigitonin, H2O and Na2CO3 and mitochondrial inner membrane vesicles wer...
متن کاملA comparative study of avermectin B1a and other modulators of the gamma-aminobutyric acid receptor . chloride ion channel complex.
The interactions of the anthelmintic agent avermectin B1a, the anticonvulsant pentobarbital, and the anxiolytic tracazolate with the gamma-aminobutyric acid (GABA) receptor . chloride ion channel complex in rat brain membrane were studied. The results indicated that they all potentiated ligand binding to the GABA and benzodiazepine receptors. The stimulatory effects of avermectin B1a and pentob...
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Acetazolamide, a carbonic anhydrase inhibitor, is used empirically in neuromuscular diseases with episodic ataxia, weakness, and myotonia, although not all of the mechanisms responsible for its therapeutic effects are understood. To elucidate whether acetazolamide acts directly on the human skeletal muscle voltage-gated chloride channel (ClC-1), which is associated with myotonia, we evaluated t...
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ژورنال
عنوان ژورنال: Journal of Experimental Biology
سال: 1989
ISSN: 1477-9145,0022-0949
DOI: 10.1242/jeb.142.1.191